GLYCAM-Web | Utilities for molecular modeling of carbohydrates

What glycans bind to my protein?

If you have access to a crystal structure of a carbohydrate bound to a protein, this tool will use that single co-complex as a basis for predicting which other similar glycans are also likely to bind to the same protein.

This tool uses carbohydrate grafting [1,2] to build 3D structures of glycan-protein structures. The tool can predict which glycans among a group that all share a common motif are likely to bind to a given protein known to recognize that motif. A motif is typically two or three monosaccharides.

Predict the glycans that bind to a protein with a known 3D co-structure.
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1. Grant, et al., Glycobiology. (2016) 26, 772-783
2. Grant, et al., Glycobiology. (2016) 26, 1027-1028
3. Grahn, et al., J. Mol. Biol.. (2007) 369, 710-761